Oral Pre-Exposure Prophylaxis - Questions and Answers


This document provides basic guidance to program managers interested in developing a PrEP implementation program.  

The document covers the following:

  • What is the current guidance?  
  • Who is PrEP for? 
  • Can PrEP bring HIV prevention to people “left behind”? 
  • What about people who are only at risk of acquiring HIV infection during certain periods? 
  • How does PrEP need to be taken? 
  • Didn’t some trials show effectiveness with fewer PrEP doses? 
  • How long does it take for PrEP to become effective in different types of tissue, and how long does this last? 
  • Is introducing PrEP leading to sexual behaviour that is less safe? 
  • Do third parties pose additional risk? 
  • Is PrEP safe? 
  • Can PrEP cause resistance to antiretroviral medicines? 
  • How can PrEP be delivered? 
  • How does PrEP fit within national HIV programmes? 
  • What authorization is needed to implement PrEP?